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KMID : 1134820130420060869
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Journal of the Korean Society of Food Science and Nutrition
2013 Volume.42 No. 6 p.869 ~ p.876
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Effect of Black Garlic and Gaeddongssuk (Artemisia annua L.) Extracts on the Lipid Profile and Hepatic Antioxidant Enzyme Activities of Exercised Rats
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Kang Jae-Ran
Lee Soo-Jung
Hwang Cho-Rong
Kim In-Sung
Sung Nak-Ju
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Abstract
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To develop functional products based on black garlic, a black garlic extract (BG) of 7 brix, a gaeddongssuk extract (GS) of 0.7 brix and two types of mixtures (MBS-Ⅰ, black garlic 7 brix:gaeddongssuk 0.7 brix; MBS-Ⅱ, black garlic 14 brix:gaeddongssuk 1.4 brix, 93:7, v/v) were supplemented to rats training on a treadmill for 4 weeks. Body weight from the training did not decrease during the experimental period. Serum albumin content significantly increased in the groups fed an experimental diet compared to the control. The BUN content significantly decreased in BG and MBS-Ⅱ groups compared to the control. AST and ALP activities significantly decreased in the groups fed an experimental diet compared to the control. Serum triglyceride and total cholesterol levels in MBS-Ⅰ and MBS-Ⅱ groups significantly decreased compared to the control. Lipid levels in the serum and liver tissue were not significantly different between the MBS-Ⅰ and MBS-Ⅱ groups. The lipid peroxide content in the serum and liver tissue was significantly reduced in the groups fed all extracts compared to the control; the serum and liver lipid contents was lowest in the MBS-Ⅰ and MBS-Ⅱ groups, respectively. Hepatic catalase activity in the GS and MBS groups increased by 1.8～2.3 times compared to the control. SOD and GSH-px activities significantly increased from treatment with the extracts by 1.3～1.5 times and 1.2～1.7 times, respectively. These results indicate that a mixture of BG and GS extracts has higher biological activity than a single supplementation of BG or GS extract. Therefore, the addition of gaeddongssuk to black garlic (MBS-Ⅰ and MBS-Ⅱ) is effective as a defense material against oxidative stress. MBS-Ⅰ may be especially effective for its biological activities.
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KEYWORD
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black garlic, gaeddongssuk, lipid profile, hepatic antioxidant enzyme, treadmill running training
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